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Anti-sporozoite antibodies and immunity to malaria in a rural Gambian population.

Abstract:

A conserved repeated epitope, (NANP)3, of the circumsporozoite protein of Plasmodium falciparum has been identified previously as a putative target for artificially induced immunity to malaria. We examined the role of humoral responses to this epitope in acquired immunity to malaria in a rural African population. Seropositivity to (NANP)3 was slow to develop (9% positive in subjects aged 1-11 years; 88% in those of 30 years and above), and responses in younger subjects were transient. The poo...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
82
Issue:
4
Pages:
532-537
Publication date:
1988-01-01
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:3e8841b6-452a-4d4e-ab1d-c1e3901302ec
Source identifiers:
184973
Local pid:
pubs:184973

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