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DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Abstract:

Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate mechanisms of resistance to angiogenesis inhibitors, we transduced human glioblastoma cells with retroviruses encoding Notch delta-like ligand 4 (DLL4), grew them as tumor xenografts and then treated the murine hosts with the VEGF-A inhibitor bevacizumab. We found that DLL4-mediated tumor resistance to bevacizumab in vivo. The large vessel...

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Authors


Sainson, RC More by this author
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Journal:
Cancer research
Volume:
71
Issue:
18
Pages:
6073-6083
Publication date:
2011-09-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:3e866ae3-d35e-40bd-bed2-f056244e0dcd
Source identifiers:
167568
Local pid:
pubs:167568

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