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An in silico analysis of trypanosomatid RNA polymerases: insights into their unusual transcription.

Abstract:

African trypanosomes employ both Pol I (RNA polymerase I) and Pol II to transcribe protein-coding genes in large polycistronic units of up to 50 genes. Subsequent processing produces mature capped mRNAs. Evidence suggests that regulation of gene expression is primarily exerted post-transcriptionally. Here, we use the recently completed genome sequences of three trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, in an in silico analysis of their fundamental RNA polyme...

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Publication status:
Published

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Publisher copy:
10.1042/bst20051435

Authors


Wickstead, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Volume:
33
Issue:
Pt 6
Pages:
1435-1437
Publication date:
2005-12-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:3e7ce23a-2fdd-4474-ae1a-6fa71c325ef4
Source identifiers:
19724
Local pid:
pubs:19724

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