Journal article
Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals
- Abstract:
-
To make good decisions, humans need to learn about and integrate different sources of appetitive and aversive information. While serotonin has been linked to value-based decision-making, its role in learning is less clear, with acute manipulations often producing inconsistent results. Here, we show that when the effects of a selective serotonin reuptake inhibitor (SSRI, citalopram) are studied over longer timescales, learning is robustly improved. We measured brain activity with functional ma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Medical Research Council
More from this funder
Grant:
MR/N014448/1
092759/Z/10/Z
Funding agency for:
Scholl, J
+ Wellcome Trust
More from this funder
Funding agency for:
Kolling, N
Rushworth, M
Scholl, J
Grant:
89280/Z/09/Z
WT100973AIA
092759/Z/10/Z
092759/Z/10/Z, 89280/Z/09/Z, WT100973AIA
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Biology Journal website
- Volume:
- 15
- Issue:
- 2
- Article number:
- e2000756
- Publication date:
- 2017-01-01
- Acceptance date:
- 2017-01-19
- DOI:
- EISSN:
-
1545-7885
- ISSN:
-
1544-9173
Item Description
- Pubs id:
-
pubs:673062
- UUID:
-
uuid:3e7022b5-3106-460d-8664-55a4b0d85556
- Local pid:
- pubs:673062
- Deposit date:
- 2017-01-25
Terms of use
- Copyright holder:
- Scholl et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Scholl et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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