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Head and other physical trauma requiring hospitalisation is not a significant risk factor in the development of ALS.

Abstract:

The pathogenesis of ALS is not fully understood but, as an overwhelmingly sporadic disorder, it is likely to result from a complex mixture of polygenic and environmental risk factors operating in the context of an ageing nervous system. Physical trauma, in particular head injury, has been variably associated with both Alzheimer's and Parkinson's disease, and largely discounted in relation to multiple sclerosis. Several case-control studies in ALS have reported an association with physical tra...

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Publication status:
Published

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Publisher copy:
10.1016/j.jns.2009.10.010

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Abisgold, J More by this author
Yeates, DG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Population Health
Journal:
Journal of the neurological sciences
Volume:
288
Issue:
1-2
Pages:
45-48
Publication date:
2010-01-05
DOI:
EISSN:
1878-5883
ISSN:
0022-510X
URN:
uuid:3e699a96-7378-4118-9c4c-a0947ad82dd6
Source identifiers:
162675
Local pid:
pubs:162675

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