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Journal article

Acute systemic inflammation impairs endothelium-dependent dilatation in humans.

Abstract:

BACKGROUND: We tested the hypothesis that endothelial dysfunction underlies the association between an acute inflammatory episode and the transiently increased risk of a cardiovascular event by examining the effects of an experimental inflammatory stimulus on endothelium-dependent vasodilation. METHODS AND RESULTS: Salmonella typhi vaccine was used to generate a systemic inflammatory response in healthy volunteers. In 12 subjects, dilatation of the brachial artery to flow and to sublingual ni...

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Publication status:
Published

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Publisher copy:
10.1161/01.CIR.102.9.994

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
Circulation
Volume:
102
Issue:
9
Pages:
994-999
Publication date:
2000-08-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
105209

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