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Journal article

T cell activation and the cytoskeleton.

Abstract:

Ligation of the T cell antigen receptor (TCR) stimulates protein tyrosine kinases (PTKs), which regulate intracellular calcium and control the activity of protein kinase C (PKC) isozymes. PTKs activated by antigen receptors and costimulatory molecules also couple to phosphatidylinositol-3 kinase (PI3K) and control the activity of Ras- and Rho-family GTPases. T cell signal transduction is triggered physiologically by antigen in the context of antigen presenting cells (APC). The formation of st...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Annual review of immunology
Volume:
18
Issue:
1
Pages:
165-184
Publication date:
2000-01-01
DOI:
EISSN:
1545-3278
ISSN:
0732-0582
URN:
uuid:3e5c5bcb-bf99-4535-b623-8213f85c5cde
Source identifiers:
2451
Local pid:
pubs:2451

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