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Chemokines: more than just road signs.

Abstract:
Chemokines have long been known to orchestrate dendritic-cell migration in the body. However, recent evidence has shown that chemokines not only direct the trafficking of dendritic cells but also can regulate their maturation status. Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming.
Publication status:
Published

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Publisher copy:
10.1038/nri1776

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Journal:
Nature reviews. Immunology
Volume:
6
Issue:
2
Pages:
159-164
Publication date:
2006-02-05
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
URN:
uuid:3e5645c5-87e2-48b2-8b0e-22a8a4354fc3
Source identifiers:
469728
Local pid:
pubs:469728

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