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Journal article

Multistep protein unfolding during nanopore translocation.

Abstract:

Cells are divided into compartments and separated from the environment by lipid bilayer membranes. Essential molecules are transported back and forth across the membranes. We have investigated how folded proteins use narrow transmembrane pores to move between compartments. During this process, the proteins must unfold. To examine co-translocational unfolding of individual molecules, we tagged protein substrates with oligonucleotides to enable potential-driven unidirectional movement through a...

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Publication status:
Published

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Publisher copy:
10.1038/nnano.2013.22

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author
Journal:
Nature nanotechnology
Volume:
8
Issue:
4
Pages:
288-295
Publication date:
2013-04-01
DOI:
EISSN:
1748-3395
ISSN:
1748-3387
Source identifiers:
387755
Language:
English
Keywords:
Pubs id:
pubs:387755
UUID:
uuid:3e55a5f5-cc01-4514-ac10-70eca0562ac5
Local pid:
pubs:387755
Deposit date:
2013-11-17

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