Journal article
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
- Abstract:
-
GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b]pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent and selective. Several examples of the series, in addition to possessing favourable pharmacokinetic profiles and analgesic activity in vivo, have also demonstrated relatively high brain penetration in the rat compared with the clinically available ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.bmcl.2004.07.089
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Authors
Bibliographic Details
- Journal:
- Bioorganic and medicinal chemistry letters
- Volume:
- 14
- Issue:
- 21
- Pages:
- 5445-5448
- Publication date:
- 2004-11-01
- DOI:
- EISSN:
-
1464-3405
- ISSN:
-
0960-894X
- Source identifiers:
-
32857
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:32857
- UUID:
-
uuid:3e532779-2daa-4502-8039-5bf9c48950ea
- Local pid:
- pubs:32857
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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