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Journal article

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

Abstract:

GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b]pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent and selective. Several examples of the series, in addition to possessing favourable pharmacokinetic profiles and analgesic activity in vivo, have also demonstrated relatively high brain penetration in the rat compared with the clinically available ...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2004.07.089

Authors


Beswick, P More by this author
Bingham, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Browning, K More by this author
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Journal:
Bioorganic and medicinal chemistry letters
Volume:
14
Issue:
21
Pages:
5445-5448
Publication date:
2004-11-05
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
URN:
uuid:3e532779-2daa-4502-8039-5bf9c48950ea
Source identifiers:
32857
Local pid:
pubs:32857

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