Abstract:

Type 1 diabetes (T1D) is a common, heritable autoimmune disease, with approximately 60 chromosome regions identified that show association with disease. Cases diagnosed at < 10 years most rapidly lose the ability to endogenously produce insulin and suffer the greatest complications of the disease, including decreased life expectancy.

I therefore analysed genotype data from 15, 645 cases and tested the association of each variant at a genome-wide level with age-at-diagnosis, in...

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