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Thesis

Statistical methods and analyses in autoimmune diseases

Abstract:

Type 1 diabetes (T1D) is a common, heritable autoimmune disease, with approximately 60 chromosome regions identified that show association with disease. Cases diagnosed at < 10 years most rapidly lose the ability to endogenously produce insulin and suffer the greatest complications of the disease, including decreased life expectancy.

I therefore analysed genotype data from 15, 645 cases and tested the association of each variant at a genome-wide level with age-at-diagnosis, in...

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Institution:
University of Oxford
Division:
MSD
Oxford college:
Brasenose College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:3e505ae8-9ed9-476f-b1bd-cb1c0368a12d
Deposit date:
2020-02-17

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