Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons.

Journal article

The majority of fast inhibitory synaptic transmission in the mammalian nervous system is mediated by GABA(A) receptors (GABA(A)Rs). Here we report a novel interaction between the protein Maf1 and GABA(A)R beta-subunit intracellular domains. We find Maf1 to be highly expressed in brain and enriched in the hippocampus and cortex. In heterologous cells and neurons we show Maf1 co-localises with GABA(A)Rs in intracellular compartments and at the cell surface. In neurons, Maf1 is found localised i...

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Authors: Smith, K; Oliver, P; Lumb, M; Arancibia-Carcamo, I; Revilla-Sanchez, R

• Publication status: Published
• Journal: Molecular and cellular neurosciences
• Volume: 44
• Issue: 4
• Pages: 330-341
• Publication date: 2010-08-01
• DOI: 10.1016/j.mcn.2010.04.004
• EISSN: 1095-9327
• ISSN: 1044-7431
• Language: English
• Keywords: Humans; Animals; Receptors, GABA-A; Rats; Male; Transfection; Mice, Inbred C57BL; Cerebral Cortex; Cells, Cultured; Repressor Proteins; Mice; Subcellular Fractions; Nerve Tissue Proteins; Hippocampus; Rats, Sprague-Dawley; Two-Hybrid System Techniques; COS Cells; Protein Binding; Cercopithecus aethiops; Protein Subunits; Neurons; Protein Transport