- Abstract:
-
Introduction: Biologics were the first targeted therapies for rheumatoid arthritis (RA), having in common high clinical efficacy. Being proteins, they are administered parenterally. The first oral targeted small molecules approved for RA are competitive inhibitors of the Janus kinase (JAK) enzyme family which mediate signalling for a cytokine subset important in RA pathogenesis. Areas covered: Several JAK inhibitors have been developed with differing selectivity for the four JAK enzymes with...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 177.9kb)
-
(pdf, 18.9kb)
-
(jpeg, 32.3kb)
-
(pdf, 16.1kb)
-
- Publisher copy:
- 10.1080/13543784.2017.1372422
-
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- Publisher:
- Taylor and Francis Publisher's website
- Journal:
- Expert Opinion on Investigational Drugs Journal website
- Volume:
- 26
- Issue:
- 10
- Pages:
- 1181-1187
- Publication date:
- 2017-08-24
- Acceptance date:
- 2017-08-24
- DOI:
- EISSN:
-
1744-7658
- ISSN:
-
1354-3784
- Pubs id:
-
pubs:725767
- URN:
-
uri:3e4afb6e-5cb2-4c28-840d-154bb0bf7cbc
- UUID:
-
uuid:3e4afb6e-5cb2-4c28-840d-154bb0bf7cbc
- Local pid:
- pubs:725767
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Taylor and Francis at: 10.1080/13543784.2017.1372422
Journal article
Filgotinib for the treatment of rheumatoid arthritis
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