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Journal article

Filgotinib for the treatment of rheumatoid arthritis

Abstract:

Introduction: Biologics were the first targeted therapies for rheumatoid arthritis (RA), having in common high clinical efficacy. Being proteins, they are administered parenterally. The first oral targeted small molecules approved for RA are competitive inhibitors of the Janus kinase (JAK) enzyme family which mediate signalling for a cytokine subset important in RA pathogenesis. Areas covered: Several JAK inhibitors have been developed with differing selectivity for the four JAK enzymes with...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1080/13543784.2017.1372422

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Department:
St Peters College
More by this author
Department:
Oxford, MSD, NDORMS
More by this author
Department:
Oxford, MSD, NDORMS
Publisher:
Taylor and Francis Publisher's website
Journal:
Expert Opinion on Investigational Drugs Journal website
Volume:
26
Issue:
10
Pages:
1181-1187
Publication date:
2017-08-24
Acceptance date:
2017-08-24
DOI:
EISSN:
1744-7658
ISSN:
1354-3784
Pubs id:
pubs:725767
URN:
uri:3e4afb6e-5cb2-4c28-840d-154bb0bf7cbc
UUID:
uuid:3e4afb6e-5cb2-4c28-840d-154bb0bf7cbc
Local pid:
pubs:725767

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