Effect of lengthening rate on angiogenesis during distraction osteogenesis.
This study investigated the angiogenic response to four varying rates (0.3, 0.7, 1.3, and 2.7 mm/day) of distraction in a rabbit model of leg-lengthening. Immunostaining was performed with use of specific antibodies to type-IV collagen and endothelial cell antigen to examine semiquantitatively the presence of blood vessels in the developing tissues. With use of the Chalkley counting method, the greatest number of positive-staining blood vessel cells was found in the central fibrous zone of th...Expand abstract
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- J Bone Jt Surgery Inc.
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
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