Journal article icon

Journal article

Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer.

Abstract:

PURPOSE: We aimed to identify signaling pathways involved in the response and resistance to aromatase inhibitor therapy in patients with breast cancer. PATIENTS AND METHODS: One hundred fourteen women with T2-4 N0-1, estrogen receptor (ER) alpha-positive tumors were randomly assigned to neoadjuvant letrozole or letrozole plus metronomic cyclophosphamide. Twenty-four tumor proteins involved in apoptosis, cell survival, hypoxia, angiogenesis, growth factor, and hormone signaling were assessed ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1200/jco.2007.13.7083

Authors


Generali, D More by this author
Berruti, A More by this author
Brizzi, MP More by this author
Expand authors...
Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume:
27
Issue:
2
Pages:
227-234
Publication date:
2009-01-05
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:3e3c99d5-6c67-4787-9bae-fd75efad1aab
Source identifiers:
293738
Local pid:
pubs:293738

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP