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Correlative microscopy of vitreous sections provides insights into BAR-domain organisation in situ

Abstract:

Electron microscopy imaging of macromolecular complexes in their native cellular context is limited by the inherent difficulty to acquire high-resolution tomographic data from thick cells and to specifically identify elusive structures within crowded cellular environments. Here, we combined cryo-fluorescence microscopy with electron cryo-tomography of vitreous sections into a coherent correlative microscopy workflow, ideal for detection and structural analysis of elusive protein assemblies in...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.str.2018.03.015

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0002-0168-0277
Hoffnann, P More by this author
Kukulski, W More by this author
Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Volume:
26
Issue:
6
Pages:
P879-886
Publication date:
2018-04-19
Acceptance date:
2018-03-22
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Pubs id:
pubs:835036
URN:
uri:3e3983ae-ab27-4790-b1ca-ed6a25469407
UUID:
uuid:3e3983ae-ab27-4790-b1ca-ed6a25469407
Local pid:
pubs:835036

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