Journal article icon

Journal article

Sequential gene targeting to make chimeric tumor models with de novo chromosomal abnormalities.

Abstract:

The discovery of chromosomal translocations in leukemia/lymphoma and sarcomas presaged a widespread discovery in epithelial tumors. With the advent of new-generation whole-genome sequencing, many consistent chromosomal abnormalities have been described together with putative driver and passenger mutations. The multiple genetic changes required in mouse models to assess the interrelationship of abnormalities and other mutations are severe limitations. Here, we show that sequential gene targeti...

Expand abstract

Actions


Access Document


Authors


Chambers, JS More by this author
Geisler, NJ More by this author
Expand authors...
Publisher:
American Association for Cancer Research Inc.
Journal:
Cancer research
Volume:
74
Issue:
5
Pages:
1588-1597
Publication date:
2014-03-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:3e308e2b-d135-480b-8122-3d131d8cdc40
Source identifiers:
460600
Local pid:
pubs:460600

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP