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Accessory cell and HLA compatibility requirements for the generation of specific in-vitro antibody responses to influenza virus by human blood lymphocytes.

Abstract:

The role of antigen presenting cells in specific in-vitro antibody responses to influenza virus by human lymphocytes was investigated. Demonstration of a requirement for accessory cells necessitated vigorous depletion procedures. Accessory cells were removed by passage of mononuclear cells through a Sephadex G10 column followed by separation of cells bearing antigens defined by the monoclonal antibodies OKM1 and UCHM1 by fluorescence-activated cell sorting or panning. Peripheral blood mononuc...

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Authors


Mitchell, DM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Winger, LA More by this author
Callard, RE More by this author
Journal:
Immunology
Volume:
50
Issue:
2
Pages:
239-250
Publication date:
1983-10-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:3e300893-0c76-4123-9f9d-b37b10b78341
Source identifiers:
35504
Local pid:
pubs:35504

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