Journal article icon

Journal article

Antidepressant drug treatment induces Arc gene expression in the rat brain.

Abstract:

The mechanism underlying the therapeutic effect of antidepressants is not known but neuroadaptive processes akin to long-term potentiation have been postulated. Arc (Activity-regulated, cytoskeletal-associated protein) is an effector immediate early gene implicated in LTP and other forms of neuroplasticity. Recent data show that Arc expression is regulated by brain 5-hydroxytryptamine neurones, a target of many antidepressants. Here in situ hybridisation and immunohistochemistry were used to ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuroscience
Volume:
121
Issue:
4
Pages:
975-982
Publication date:
2003-01-01
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:3e1b223c-c2df-42fd-b5ef-8ffad3dc03a0
Source identifiers:
185156
Local pid:
pubs:185156

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP