- Abstract:
-
The mechanism underlying the therapeutic effect of antidepressants is not known but neuroadaptive processes akin to long-term potentiation have been postulated. Arc (Activity-regulated, cytoskeletal-associated protein) is an effector immediate early gene implicated in LTP and other forms of neuroplasticity. Recent data show that Arc expression is regulated by brain 5-hydroxytryptamine neurones, a target of many antidepressants. Here in situ hybridisation and immunohistochemistry were used to ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0306-4522(03)00504-9
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- Journal:
- Neuroscience
- Volume:
- 121
- Issue:
- 4
- Pages:
- 975-982
- Publication date:
- 2003-01-01
- DOI:
- EISSN:
-
1873-7544
- ISSN:
-
0306-4522
- URN:
-
uuid:3e1b223c-c2df-42fd-b5ef-8ffad3dc03a0
- Source identifiers:
-
185156
- Local pid:
- pubs:185156
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Antidepressant drug treatment induces Arc gene expression in the rat brain.
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