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Journal article

ATM activation and signaling under hypoxic conditions.

Abstract:

The ATM kinase has previously been shown to respond to the DNA damage induced by reoxygenation following hypoxia by initiating a Chk 2-dependent cell cycle arrest in the G(2) phase. Here we show that ATM is both phosphorylated and active during exposure to hypoxia in the absence of DNA damage, detectable by either comet assay or 53BP1 focus formation. Hypoxia-induced activation of ATM correlates with oxygen concentrations low enough to cause a replication arrest and is entirely independent of...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.01301-08

Authors


Bencokova, Z More by this author
Kaufmann, MR More by this author
Lecane, PS More by this author
Giaccia, AJ More by this author
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Journal:
Molecular and cellular biology
Volume:
29
Issue:
2
Pages:
526-537
Publication date:
2009-01-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:3e099c07-a145-4009-96c3-889662ce9836
Source identifiers:
131222
Local pid:
pubs:131222

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