Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

Journal article

TNF is a key factor in a variety of inflammatory diseases. Here we report that TNF induced pro-inflammatory cytokine synthesis of IL-6 and IL-8 is mediated by the Rho GTPase Rac. TNF induces p42/p44, p54 and p38 MAPK kinase; these kinases have been implicated in control of cytokine synthesis. However, over-expression of a dominant negative form of Rac strongly inhibited TNF-induced p42/44 MAPK kinase activation, but had little effect upon JNK and no effect upon p38 MAPK activity. Another key ...

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Authors: Williams, L; Lali, F; Willetts, K; Balague, C; Godessart, N

• Publication status: Published
• Journal: Molecular immunology
• Volume: 45
• Issue: 9
• Pages: 2446-2454
• Publication date: 2008-05-01
• DOI: 10.1016/j.molimm.2007.12.011
• EISSN: 1872-9142
• ISSN: 0161-5890
• Language: English
• Keywords: Cell Line; NF-kappa B; Tumor Necrosis Factor-alpha; Interleukin-6; Interleukin-8; rac GTP-Binding Proteins; Mitogen-Activated Protein Kinase Kinases; Cells, Cultured; Fibroblasts; Humans