An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

Journal article

AIMS/HYPOTHESIS: Pathophysiological similarities between latent autoimmune diabetes in adults (LADA) and type 1 diabetes indicate an overlap in genetic susceptibility. HLA-DRB1 and HLA-DQB1 are major susceptibility genes for type 1 diabetes but studies of these genes in LADA have been limited. Our aim was to define patterns of HLA-encoded susceptibility/protection in a large, well characterised LADA cohort, and to establish association with disease and age at diagnosis. MATERIALS AND METHODS...

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Authors: Desai, M; Zeggini, E; Horton, V; Owen, K; Hattersley, A

• Publication status: Published
• Journal: Diabetologia
• Volume: 50
• Issue: 1
• Pages: 68-73
• Publication date: 2007-01-01
• DOI: 10.1007/s00125-006-0513-z
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Female; Humans; Genetic Predisposition to Disease; HLA-DQ Antigens; Genotype; Gene Frequency; Cohort Studies; Diabetes Mellitus, Type 1; Haplotypes; Middle Aged; Aged, 80 and over; Male; Aged; HLA-DR Antigens; Great Britain; Linear Models; Adult; Case-Control Studies