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Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes.

Abstract:

The effects of raised insulin resistance and decreased beta-cell function on basal plasma glucose and insulin concentrations have been estimated by means of a mathematical model which uses the available data on control of glucose and insulin flux. The model shows that near-normal basal plasma insulin levels could be maintained by means of basal hyperglycaemia when beta-cell function is deficient. The hyperglycaemia does not become pronounced until more than 80% of beta-cell function has been ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Lancet
Volume:
1
Issue:
8272
Pages:
596-598
Publication date:
1982-03-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Source identifiers:
24712
Language:
English
Keywords:
Pubs id:
pubs:24712
UUID:
uuid:3e04d716-f1b5-46c3-8073-8b264c32c34c
Local pid:
pubs:24712
Deposit date:
2012-12-19

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