- Abstract:
-
The effects of raised insulin resistance and decreased beta-cell function on basal plasma glucose and insulin concentrations have been estimated by means of a mathematical model which uses the available data on control of glucose and insulin flux. The model shows that near-normal basal plasma insulin levels could be maintained by means of basal hyperglycaemia when beta-cell function is deficient. The hyperglycaemia does not become pronounced until more than 80% of beta-cell function has been ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0140-6736(82)91753-6
-
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- Journal:
- Lancet
- Volume:
- 1
- Issue:
- 8272
- Pages:
- 596-598
- Publication date:
- 1982-03-05
- DOI:
- EISSN:
-
1474-547X
- ISSN:
-
0140-6736
- URN:
-
uuid:3e04d716-f1b5-46c3-8073-8b264c32c34c
- Source identifiers:
-
24712
- Local pid:
- pubs:24712
- Language:
- English
- Keywords:
- Copyright date:
- 1982
Journal article
Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes.
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