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Relative contributions of insulin deficiency and insulin resistance in maturity-onset diabetes.

Abstract:

The effects of raised insulin resistance and decreased beta-cell function on basal plasma glucose and insulin concentrations have been estimated by means of a mathematical model which uses the available data on control of glucose and insulin flux. The model shows that near-normal basal plasma insulin levels could be maintained by means of basal hyperglycaemia when beta-cell function is deficient. The hyperglycaemia does not become pronounced until more than 80% of beta-cell function has been ...

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Publication status:
Published

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Authors


Turner, RC More by this author
Mathews, DR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
Journal:
Lancet
Volume:
1
Issue:
8272
Pages:
596-598
Publication date:
1982-03-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:3e04d716-f1b5-46c3-8073-8b264c32c34c
Source identifiers:
24712
Local pid:
pubs:24712

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