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Thesis

Investigating the role of serine-ADP-ribosylation in human cells

Abstract:

ADP-ribosylation (ADPr) is a widespread post-translational modification that controls many cellular processes, in particular DNA repair. Poly(ADP-ribose) polymerase 1 (PARP1) is the main ADPr enzyme that performs about 85-90% of DNA damage-induced ADPr. In response to DNA damage, PARP1 rapidly binds to DNA ends at the sites of DNA damage and modifies itself, histones and other proteins, thus promoting and regulating DNA repair. However, despite the critical role of PARP1 in DNA repair, for...

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Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Supervisor
More from this funder
Name:
Clarendon Fund
Funder identifier:
http://dx.doi.org/10.13039/501100014748
Funding agency for:
Ahel, I
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Deposit date:
2023-02-15

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