Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins.

Journal article

Tumor necrosis factor (TNF) activity was inhibited during the development of actively-induced, chronic relapsing experimental allergic encephalomyelitis (CREAE) in Biozzi AB/H mice, using a mouse TNF-specific (TN3.19.12) antibody and bivalent human p55 and p75 TNF receptor-immunoglobulin (TNFR-Ig) fusion proteins. The development of disease could be inhibited when repeated doses of antibody were administered prior to the anticipated onset. It has now also been shown that a therapeutic effect ...

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Authors: Baker, D; Butler, D; Scallon, B; O'Neill, J; Turk, J

• Publication status: Published
• Journal: European journal of immunology
• Volume: 24
• Issue: 9
• Pages: 2040-2048
• Publication date: 1994-09-01
• DOI: 10.1002/eji.1830240916
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Encephalomyelitis, Autoimmune, Experimental; Fluorescent Antibody Technique; Central Nervous System; Recombinant Fusion Proteins; Oxazolone; Mice, Inbred Strains; Mice; Animals; Immunoglobulins; Immunotherapy; Tumor Necrosis Factor-alpha; Cell Division; Antibodies, Monoclonal; Receptors, Tumor Necrosis Factor