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Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications

Abstract:

Microsatellite instability has been reported in a wide variety of cancer types. Inactivation or loss of tumour suppressor genes has been shown to result in cell cycle deregulation and neoplastic growth. We conducted a microsatellite study using fluorescent-based DNA technology to determine whether mutations in the microsatellite sequences of the deleted in colorectal cancer (DCC) gene, a tumour suppressor at 18q21.1, have any pathologic correlation or prognostic significance in nephroblastoma...

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Publication status:
Published

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Publisher copy:
10.1038/modpathol.3800022

Authors


Ramburan, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Hadley, GP More by this author
Govender, D More by this author
Journal:
MODERN PATHOLOGY
Volume:
17
Issue:
1
Pages:
89-95
Publication date:
2004-01-05
DOI:
EISSN:
1530-0285
ISSN:
0893-3952
URN:
uuid:3df5d909-1774-4f59-8774-a00609fcede9
Source identifiers:
122165
Local pid:
pubs:122165
Language:
English
Keywords:

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