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Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications

Abstract:

Microsatellite instability has been reported in a wide variety of cancer types. Inactivation or loss of tumour suppressor genes has been shown to result in cell cycle deregulation and neoplastic growth. We conducted a microsatellite study using fluorescent-based DNA technology to determine whether mutations in the microsatellite sequences of the deleted in colorectal cancer (DCC) gene, a tumour suppressor at 18q21.1, have any pathologic correlation or prognostic significance in nephroblastoma...

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Publication status:
Published

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Publisher copy:
10.1038/modpathol.3800022

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
Journal:
MODERN PATHOLOGY
Volume:
17
Issue:
1
Pages:
89-95
Publication date:
2004-01-01
DOI:
EISSN:
1530-0285
ISSN:
0893-3952
Source identifiers:
122165
Language:
English
Keywords:
Pubs id:
pubs:122165
UUID:
uuid:3df5d909-1774-4f59-8774-a00609fcede9
Local pid:
pubs:122165
Deposit date:
2012-12-19

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