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Lifelong corticosterone level determines age-related decline in neurogenesis and memory.

Abstract:

Ageing is accompanied by an alteration of spatial memory, a decline in hippocampal neurogenesis and a dysregulation of the hypothalamic-pituitary axis (HPA) leading to elevated levels of circulating corticosterone. However, the role of the HPA axis in age-related decline in cognitive functions and in neurogenesis decline remains unclear. We found that suppression of glucocorticoids secretion from midlife to the rest of the animals' life increases neurogenesis in old animals and prevents the e...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
Neurobiology of aging
Volume:
27
Issue:
4
Pages:
645-654
Publication date:
2006-04-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:3de87cc8-190e-4fb5-84e0-5ab09564f5a2
Source identifiers:
329240
Local pid:
pubs:329240

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