Journal article
Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity.
- Abstract:
-
CD4+CD25+ regulatory T cells (Treg) are known to influence T cell responses to tumours. Here we have explored the role of Treg in inhibiting not only adaptive, but also innate immune responses to tumours. To this end we used a Fas ligand (FasL)-expressing melanoma cell line in a mouse model. In this system, innate immunity is sufficient to reject the tumour. All mice depleted of Treg and challenged with FasL-expressing melanoma remained tumour-free. Investigation of the underlying cellular ef...
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- Publisher copy:
- 10.1002/eji.200636593
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Authors
Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 37
- Issue:
- 3
- Pages:
- 758-767
- Publication date:
- 2007-03-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
10136
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:10136
- UUID:
-
uuid:3de76ea4-5530-431f-8f2d-b57939e4e5c1
- Local pid:
- pubs:10136
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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