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Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity.

Abstract:

CD4+CD25+ regulatory T cells (Treg) are known to influence T cell responses to tumours. Here we have explored the role of Treg in inhibiting not only adaptive, but also innate immune responses to tumours. To this end we used a Fas ligand (FasL)-expressing melanoma cell line in a mouse model. In this system, innate immunity is sufficient to reject the tumour. All mice depleted of Treg and challenged with FasL-expressing melanoma remained tumour-free. Investigation of the underlying cellular ef...

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Publisher copy:
10.1002/eji.200636593

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Molecular Medicine
Role:
Author
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Journal:
European journal of immunology
Volume:
37
Issue:
3
Pages:
758-767
Publication date:
2007-03-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:3de76ea4-5530-431f-8f2d-b57939e4e5c1
Source identifiers:
10136
Local pid:
pubs:10136

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