Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.

Journal article

Certain pathogenic bacteria produce and release toxic peptides to ensure either nutrient availability or evasion from the immune system. These peptides are also toxic to the producing bacteria that utilize dedicated ABC transporters to provide self-immunity. The ABC transporter McjD exports the antibacterial peptide MccJ25 in Escherichia coli Our previously determined McjD structure provided some mechanistic insights into antibacterial peptide efflux. In this study, we have determined its str...

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Authors: Bountra, K; Hagelueken, G; Choudhury, H; Corradi, V; El Omari, K

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: European Molecular Biology Organization Press
• Journal: EMBO Journal
• Volume: 36
• Issue: 20
• Pages: 3062-3079
• Publication date: 2017-09-01
• Acceptance date: 2017-08-09
• DOI: 10.15252/embj.201797278
• EISSN: 1460-2075
• ISSN: 0261-4189
• Pmid: 28864543
• Language: English
• Keywords: Escherichia coli; Escherichia coli Proteins; Models, Molecular; transporter structure; Protein Transport; Crystallography, X-Ray; Protein Conformation; molecular dynamics; PELDOR; membrane protein; ATP-Binding Cassette Transporters; Molecular Dynamics Simulation; Bacteriocins; antibacterial peptide ABC transporter