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Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.

Abstract:

Certain pathogenic bacteria produce and release toxic peptides to ensure either nutrient availability or evasion from the immune system. These peptides are also toxic to the producing bacteria that utilize dedicated ABC transporters to provide self-immunity. The ABC transporter McjD exports the antibacterial peptide MccJ25 in Escherichia coli Our previously determined McjD structure provided some mechanistic insights into antibacterial peptide efflux. In this study, we have determined its str...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/embj.201797278

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Oxford college:
Magdalen College
Role:
Author
ORCID:
0000-0003-3506-6045
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Contributors

Department:
Rutherford Appleton Laboratory, Research Complex at Harwell, Oxfordshire, UK.
Swedish Research Council More from this funder
Alberta Innovates More from this funder
Publisher:
European Molecular Biology Organization Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
36
Issue:
20
Pages:
3062-3079
Publication date:
2017-09-05
Acceptance date:
2017-08-09
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:725897
URN:
uri:3de624da-17f6-4cef-9aa9-6b16451cf7f5
UUID:
uuid:3de624da-17f6-4cef-9aa9-6b16451cf7f5
Local pid:
pubs:725897

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