Journal article

Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes

Abstract:: Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.

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APA Style

Bicknell, K., Coxon, C., & Brooks, G. (2004). Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes. Biochemical Journal, 382(2), 411–416.

MLA Style

Bicknell, K., et al. “Forced Expression of the Cyclin B1-CDC2 Complex Induces Proliferation in Adult Rat Cardiomyocytes.” Biochemical Journal, vol. 382, no. 2, 2004, pp. 411–16.

Chicago Style

Bicknell, K, C Coxon, and G Brooks. 2004. “Forced Expression of the Cyclin B1-CDC2 Complex Induces Proliferation in Adult Rat Cardiomyocytes.” Biochemical Journal 382 (2): 411–16.
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Publisher copy:: 10.1042/BJ20031481

Authors

+ Bicknell, K More by this author

Role:

Author

+ Coxon, C More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Physiology Anatomy & Genetics

Role:

Author

+ Brooks, G More by this author

Role:

Author

Bibliographic Details

Journal:: Biochemical Journal More from this journal
Volume:: 382
Issue:: 2
Pages:: 411-416
Publication date:: 2004-09-01
DOI:: 10.1042/BJ20031481
ISSN:: 0264-6021

Item Description

Language:: English
Keywords:: Cardiomyocyte

Cell division

CDC2

Cyclin B

Cell cycle
Pubs id:: pubs:291284
UUID:: uuid:3de4bcfb-2417-4e6d-b8c3-e29b47c0c4eb
Local pid:: pubs:291284
Source identifiers:: 291284
Deposit date:: 2013-11-17

Terms of use

Copyright date:: 2004

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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