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Journal article

Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer.

Abstract:

Utrophin is highly homologous and structurally similar to dystrophin, and in gene delivery experiments in mdx mice was able to functionally replace dystrophin. We performed mini-utrophin gene transfer in Golden Retriever dogs with canine muscular dystrophy (CXMD). Unlike the mouse model, the clinicopathological phenotype of CXMD is similar to that of Duchenne muscular dystrophy (DMD). We injected an adenoviral vector expressing a synthetic utrophin into tibialis anterior muscles of newborn do...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301941

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Journal:
Gene therapy
Volume:
10
Issue:
9
Pages:
750-757
Publication date:
2003-05-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:3de1ea2f-97fe-44b4-b9c8-5dd63392a0a0
Source identifiers:
106676
Local pid:
pubs:106676

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