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Journal article

SpoIIIE mechanism of directional translocation involves target search coupled to sequence-dependent motor stimulation.

Abstract:

SpoIIIE/FtsK are membrane-anchored, ATP-fuelled, directional motors responsible for chromosomal segregation in bacteria. Directionality in these motors is governed by interactions between specialized sequence-recognition modules (SpoIIIE-γ/FtsK-γ) and highly skewed chromosomal sequences (SRS/KOPS). Using a new combination of ensemble and single-molecule methods, we dissect the series of steps required for SRS localization and motor activation. First, we demonstrate that SpoIIIE/DNA associatio...

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Publication status:
Published

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Publisher copy:
10.1038/embor.2013.39

Authors


Cattoni, DI More by this author
Godefroy, C More by this author
Margeat, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
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Journal:
EMBO reports
Volume:
14
Issue:
5
Pages:
473-479
Publication date:
2013-05-05
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
URN:
uuid:3de06b3c-b03d-41a1-8856-5eb7699d7dcf
Source identifiers:
394973
Local pid:
pubs:394973

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