No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.
OBJECTIVES: The aim of this study was to test the effects of the KIF6 Trp719Arg polymorphism (rs20455) on vascular risk and response to statin therapy in 18,348 participants from the Heart Protection Study. BACKGROUND: There have been claims that noncarriers of the KIF6 719Arg variant receive little benefit from statin therapy. Screening for this genetic variant is now being used to influence statin use. METHODS: Participants received 40 mg simvastatin daily for 4 to 6 weeks before being rand...Expand abstract
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