Journal article icon

Journal article

No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.

Abstract:

OBJECTIVES: The aim of this study was to test the effects of the KIF6 Trp719Arg polymorphism (rs20455) on vascular risk and response to statin therapy in 18,348 participants from the Heart Protection Study. BACKGROUND: There have been claims that noncarriers of the KIF6 719Arg variant receive little benefit from statin therapy. Screening for this genetic variant is now being used to influence statin use. METHODS: Participants received 40 mg simvastatin daily for 4 to 6 weeks before being rand...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jacc.2011.02.015

Authors


Hopewell, JC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Armitage, J More by this author
Expand authors...
Journal:
Journal of the American College of Cardiology
Volume:
57
Issue:
20
Pages:
2000-2007
Publication date:
2011-05-05
DOI:
EISSN:
1558-3597
ISSN:
0735-1097
URN:
uuid:3dcc2e09-3f86-4163-801e-b57d75844f23
Source identifiers:
149884
Local pid:
pubs:149884

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP