- Abstract:
-
The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we identify a polymorphic p53 responsive element and demonstrate its influence on cancer risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, and p53-binding sites. We uncover a single-nucleotide polymorphism (SNP) in a functional p53-binding site and establish its influ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.cell.2013.09.017
-
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- Journal:
- Cell
- Volume:
- 155
- Issue:
- 2
- Pages:
- 410-422
- Publication date:
- 2013-10-05
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- URN:
-
uuid:3dc52510-9bee-4da6-bf81-88ff2254ba58
- Source identifiers:
-
433801
- Local pid:
- pubs:433801
- Copyright date:
- 2013
Journal article
A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection.
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