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A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection.

Abstract:

The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we identify a polymorphic p53 responsive element and demonstrate its influence on cancer risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, and p53-binding sites. We uncover a single-nucleotide polymorphism (SNP) in a functional p53-binding site and establish its influ...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2013.09.017

Authors


Zeron-Medina, J More by this author
Campbell, MR More by this author
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Journal:
Cell
Volume:
155
Issue:
2
Pages:
410-422
Publication date:
2013-10-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:3dc52510-9bee-4da6-bf81-88ff2254ba58
Source identifiers:
433801
Local pid:
pubs:433801

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