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DNA modifications: naturally more error prone?

Abstract:

Epigenetic DNA modifications are essential for normal cell function in vertebrates, but they can also be hotspots of mutagenesis. Methylcytosine in particular has long been known to be less stable than other nucleotides and spontaneously deaminates to thymine. Beyond this well-established phenomenon, however, the influence of epigenetic marks on mutagenesis has recently become an active field of investigation. In this review, we summarize current knowledge of the interactions between differen...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.tig.2018.04.005

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Ludwig Cancer Research More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Trends in Genetics Journal website
Volume:
34
Issue:
8
Pages:
627-638
Publication date:
2018-05-28
Acceptance date:
2018-04-27
DOI:
ISSN:
0168-9525
Pubs id:
pubs:854222
URN:
uri:3db919f8-074a-480b-abb9-3977005f8a93
UUID:
uuid:3db919f8-074a-480b-abb9-3977005f8a93
Local pid:
pubs:854222

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