Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

Journal article

CD28 was thought to represent a prototypic membrane receptor responsible for delivering the classically defined 'second signal' needed to avoid T cell paralysis when recognizing antigen presented by appropriate antigen presenting cells (APCs). Almost two decades after its molecular identification, the mechanism by which this 'second receptor' facilitates clonal expansion and differentiation upon antigen encounter is still not fully elucidated. There may be at least two reasons for this partia...

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Authors: Acuto, O; Mise-Omata, S; Mangino, G; Michel, F

• Publication status: Published
• Journal: Immunological reviews
• Volume: 192
• Issue: 1
• Pages: 21-31
• Publication date: 2003-04-01
• DOI: 10.1034/j.1600-065x.2003.00034.x
• EISSN: 1600-065X
• ISSN: 0105-2896
• Language: English
• Keywords: Antigen-Presenting Cells; Humans; Antigens, CD28; T-Lymphocytes; Models, Immunological; Signal Transduction; Receptors, Antigen, T-Cell; Mice; Lymphocyte Activation; Animals