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A simplified method for generating Purkinje cells from human-induced pluripotent stem cells

Abstract:

The establishment of a reliable model for the study of Purkinje cells in vitro is of particular importance, given their central role in cerebellar function and pathology. Recent advances in induced pluripotent stem cell (iPSC) technology offer the opportunity to generate multiple neuronal subtypes for study in vitro. However, to date, only a handful of studies have generated Purkinje cells from human pluripotent stem cells, with most of these protocols proving challenging to reproduce. Here, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s12311-017-0913-2

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0002-5238-4902
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Grant:
090532/Z/09/Z
WTISSF121302
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Grant:
H2020 Marie Skłodowska-Curie Actions 699978
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Grant:
Monument Trust Discovery Award
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Publisher:
Springer US Publisher's website
Journal:
Cerebellum Journal website
Volume:
17
Issue:
4
Pages:
419–427
Publication date:
2018-02-03
Acceptance date:
2017-12-18
DOI:
EISSN:
1473-4230
ISSN:
1473-4222
Pmid:
29397531
Source identifiers:
823121
Language:
English
Keywords:
Pubs id:
pubs:823121
UUID:
uuid:3db1bb6c-bbcd-4613-a610-4aa99d0cbfa0
Local pid:
pubs:823121
Deposit date:
2018-02-08

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