Journal article
One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen
- Abstract:
-
Many promising vaccine candidates from pathogenic viruses, bacteria, and parasites are unstable and cannot be produced cheaply for clinical use. For instance, Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is essential for erythrocyte invasion, is highly conserved among field isolates, and elicits antibodies that neutralize in vitro and protect in an animal model, making it a leading malaria vaccine candidate. However, functional RH5 is only expressible in eukaryotic sys...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Israel Science Foundation
More from this funder
Funding agency for:
Fleishman, S
Grant:
106917/Z/15/Z
+ European Research Council
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Funding agency for:
Fleishman, S
Grant:
106917/Z/15/Z
+ Wellcome Trust
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Funding agency for:
Campeotto, I
Draper, S
Higgins, M
Fleishman, S
Grant:
106917/Z/15/Z
106917/Z/15/Z
106917/Z/15/Z
106917/Z/15/Z
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Science Journal website
- Volume:
- 114
- Issue:
- 5
- Pages:
- 998-1002
- Publication date:
- 2017-01-31
- Acceptance date:
- 2016-12-16
- DOI:
- ISSN:
-
1091-6490
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:671733
- UUID:
-
uuid:3da9cfb8-edef-499c-94de-93967db6107b
- Local pid:
- pubs:671733
- Source identifiers:
-
671733
- Deposit date:
- 2017-02-07
Terms of use
- Copyright holder:
- © 2017 National Academy of Sciences
- Copyright date:
- 2017
- Notes:
- © 2017 National Academy of Sciences. This article is freely available online through the PNAS open access option, see: 10.1073/pnas.1616903114
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