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Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients.

Abstract:

Major histocompatibility complex class I-related chain A (MICA) molecules are frequently expressed in lymphoproliferative malignancies including multiple myeloma (MM). MICA activates NK cells and co-stimulates T cells by interaction with its immunoreceptor NKG2D. In contrast, soluble MICA (sMICA) molecules impair the functions of NKG2D(+) T and NK cells, which may facilitate tumor cell escape from immunosurveillance. Here, we analyzed the clinical relevance of sMICA in 97 MM patients. sMICA (...

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Publisher copy:
10.1016/j.clim.2006.11.007

Authors


Rebmann, V More by this author
Schütt, P More by this author
Brandhorst, D More by this author
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Journal:
Clinical immunology (Orlando, Fla.)
Volume:
123
Issue:
1
Pages:
114-120
Publication date:
2007-04-05
DOI:
EISSN:
1521-7035
ISSN:
1521-6616
URN:
uuid:3d9a9d10-15bd-48b1-b36a-5a5c485b7f3b
Source identifiers:
273697
Local pid:
pubs:273697

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