Journal article
Single-molecule protein phosphorylation and dephosphorylation by nanopore enzymology
- Abstract:
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Reversible protein phosphorylation plays a crucial and ubiquitous role in the control of almost all cellular processes. The interplay of protein kinases and phosphatases acting in opposition ensures tight dynamic control of protein phosphorylation states within the cell. Previously, engineered alpha-hemolysin pores bearing kinase substrate peptides have been developed as single-molecule stochastic sensors for protein kinases. Here, we have used these pores to observe, label-free, the phosphor...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 779.0KB)
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- Publisher copy:
- 10.1021/acsnano.8b07697
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Authors
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- ACS Nano Journal website
- Volume:
- 13
- Issue:
- 1
- Pages:
- 633-641
- Publication date:
- 2018-12-27
- Acceptance date:
- 2018-12-27
- DOI:
- EISSN:
-
1936-086X
- ISSN:
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1936-0851
- Pmid:
-
30588793
- Source identifiers:
-
963695
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:963695
- UUID:
-
uuid:3d987481-1741-494b-a9a1-99511ed79cca
- Local pid:
- pubs:963695
- Deposit date:
- 2019-03-26
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/acsnano.8b07697
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