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Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.

Abstract:

HIV-specific CTL play a central role in immune control of HIV. The basis for understanding the success or failure of this immune response requires identification of the specific epitopes targeted by CTL. However, in populations most severely affected by the global epidemic, this fundamental knowledge is hindered by the lack of characterization of many of the HLA class I alleles highly prevalent in such populations. Overall, the peptide-binding motif has been determined for a small minority (9...

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Publisher copy:
10.4049/jimmunol.176.8.4699

Authors


Honeyborne, I More by this author
Ramduth, D More by this author
Moodley, E More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
176
Issue:
8
Pages:
4699-4705
Publication date:
2006-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:3d97f1fb-6647-49d6-85cc-7ce9acd5d05d
Source identifiers:
191146
Local pid:
pubs:191146

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