Responses to analogues of growth hormone-releasing hormone in normal subjects, and in growth-hormone deficient children and young adults.

Journal article

Three analogues of growth hormone-releasing hormone (GHRH) have been compared in normal subjects. GHRH(1-29)NH2 is equipotent to GHRH(1-40); increasing doses from 10-200 micrograms per subject augments the duration of stimulated growth hormone (GH) release, but the peak serum GH shows only a poor correlation with dose. The derivative D-Ala2-GHRH(1-29)NH2 is no more potent than the unsubstituted GHRH(1-29)NH2. In 20 children and young adults with growth hormone deficiency by conventional crite...

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Authors: Grossman, A; Savage, M; Lytras, N; Preece, M; Sueiras-Diaz, J

• Publication status: Published
• Journal: Clinical endocrinology
• Volume: 21
• Issue: 3
• Pages: 321-330
• Publication date: 1984-09-01
• DOI: 10.1111/j.1365-2265.1984.tb03477.x
• EISSN: 1365-2265
• ISSN: 0300-0664
• Language: English
• Keywords: Dose-Response Relationship, Drug; Growth Hormone-Releasing Hormone; Adolescent; Peptide Fragments; Child; Humans; Adult; Female; Male; Growth Hormone; Sermorelin