Comparison of relapse and treatment failure rates among patients with neuromyelitis optica: multicenter study of treatment efficacy.

Journal article

IMPORTANCE: Neuromyelitis optica (NMO) is an inflammatory disease of the optic nerves and spinal cord that leads to blindness and paralysis. Effective immunosuppression is the standard of care for relapse prevention. OBJECTIVE: To compare the relapse and treatment failure rates among patients receiving the 3 most common forms of immunosuppression for NMO: azathioprine, mycophenolate mofetil, and rituximab. DESIGN, SETTING, AND PARTICIPANTS: We performed a retrospective, multicenter analysis o...

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Authors: Mealy, M; Wingerchuk, D; Palace, J; Greenberg, B; Levy, M

• Publication status: Published
• Journal: JAMA neurology
• Volume: 71
• Issue: 3
• Pages: 324-330
• Publication date: 2014-03-01
• DOI: 10.1001/jamaneurol.2013.5699
• EISSN: 2168-6157
• ISSN: 2168-6149
• Language: English
• Keywords: Child, Preschool; Retrospective Studies; Humans; Young Adult; Mycophenolic Acid; Recurrence; Adult; Middle Aged; Aged; Azathioprine; Female; Treatment Failure; Remission Induction; Child; Neuromyelitis Optica; Antibodies, Monoclonal, Murine-Derived; Adolescent; Treatment Outcome; Male