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Journal article

Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a.

Abstract:

BACKGROUND: X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-coding RNA Xist. As such, correct regulation of the Xist gene promoter is required to establish appropriate X chromosome activity both in males and females. Studies to date have demonstrated co-transcription of an antisense RNA Tsix and low-level sense transcription prior to...

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Publication status:
Published

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Publisher copy:
10.1186/1756-8935-1-2

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Journal:
Epigenetics and chromatin
Volume:
1
Issue:
1
Pages:
2
Publication date:
2008-01-01
DOI:
EISSN:
1756-8935
ISSN:
1756-8935
URN:
uuid:3d87eeff-a599-430d-ab02-52e59065792c
Source identifiers:
99912
Local pid:
pubs:99912
Language:
English

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