Journal article
ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting anti-flaviviral activity
- Abstract:
-
Iminosugars have therapeutic potential against a range of diseases, due to their efficacy as glycosidase inhibitors. A major challenge in the development of iminosugar drugs lies in making a compound that is selective for the glycosidase associated with a given disease. We report the synthesis of ToP-DNJ, an antiviral iminosugar-tocopherol conjugate. Tocopherol was incorporated into the design of the iminosugar in order to direct the drug to the liver and immune cells, specific tissues of int...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Lerner–Fink Fellowship
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Unither Virology LLC
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Oxford Glycobiology Endowment
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- ACS Chemical Biology Journal website
- Volume:
- 13
- Issue:
- 1
- Pages:
- 60–65
- Publication date:
- 2017-11-21
- Acceptance date:
- 2017-11-19
- DOI:
- EISSN:
-
1554-8937
- ISSN:
-
1554-8929
- Pmid:
-
29161006
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:794740
- UUID:
-
uuid:3d840605-2e42-412b-bd67-cba4d43cc08d
- Local pid:
- pubs:794740
- Source identifiers:
-
794740
- Deposit date:
- 2017-11-22
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- © 2017 American Chemical Society. ACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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