Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients.

Journal article

Between 1990 and 1994, a series of prospective studies were conducted to optimize the treatment of multidrug-resistant falciparum malaria on the borders of Thailand. The tolerance of various treatment regimens containing either mefloquine 15 mg/kg (M15) or 25 mg/kg (M25) was evaluated in 3673 patients aged between 6 months and 88 years. Early vomiting (within 1 hour) is an important determinant of treatment outcome in these areas, despite re-administration of the dose. Overall, 7 % of the pat...

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Authors: ter Kuile, F; Nosten, F; Luxemburger, C; Kyle, D; Teja-Isavatharm, P

• Publication status: Published
• Journal: Bulletin of the World Health Organization
• Volume: 73
• Issue: 5
• Pages: 631-642
• Publication date: 1995-01-01
• EISSN: 1564-0604
• ISSN: 0042-9686
• Language: English
• Keywords: Sleep Disorders; Prospective Studies; Drug Resistance, Multiple; Male; Dizziness; Antimalarials; Child; Child, Preschool; Humans; Aged, 80 and over; Adolescent; Acute Disease; Middle Aged; Infant; Mefloquine; Adult; Malaria, Falciparum; Aged; Female; Gastrointestinal Diseases