Differential phosphorylation of neuronal substrates by catalytic subunits of Aplysia cAMP-dependent protein kinase with alternative N termini.

Journal article

cAMP-dependent protein kinase (PKA) is an important participant in neuronal modulation: the ability of neurons to change their properties in response to external stimuli. In Aplysia mechanosensory neurons, PKA plays roles in both short and long term presynaptic facilitation, which is a simple model for learning and memory. PKA in Aplysia is a collection of structurally and functionally diverse regulatory and catalytic (C) subunits. We have argued that this diversity may in part account for th...

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Authors: Panchal, R; Cheley, S; Bayley, H

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 269
• Issue: 38
• Pages: 23722-23730
• Publication date: 1994-09-01
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Animals; Molecular Sequence Data; Structure-Activity Relationship; Myristates; Phosphorylation; Aplysia; Kinetics; Nerve Tissue Proteins; Isoenzymes; Base Sequence; DNA Primers; Substrate Specificity; Cyclic AMP-Dependent Protein Kinases; Recombinant Proteins; Protein Processing, Post-Translational