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Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

Abstract:

Cytotoxic T lymphocytes (CTL) can respond to a few viral peptide-MHC-I (pMHC-I) complexes among a myriad of virus-unrelated endogenous self pMHC-I complexes displayed on virus-infected cells. To elucidate the molecular recognition events on live CTL, we have utilized a self-assembled biosensor composed of semiconductor nanocrystals, quantum dots, carrying a controlled number of virus-derived (cognate) and other (noncognate) pMHC-I complexes and examined their recognition by antigen-specific T...

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Publisher copy:
10.1073/pnas.0607771103

Authors


Anikeeva, N More by this author
Lebedeva, T More by this author
Goldman, ER More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
103
Issue:
45
Pages:
16846-16851
Publication date:
2006-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:3d7a78d9-5bcb-41aa-a435-f5bdd5de567a
Source identifiers:
482604
Local pid:
pubs:482604

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