- Abstract:
-
Cytotoxic T lymphocytes (CTL) can respond to a few viral peptide-MHC-I (pMHC-I) complexes among a myriad of virus-unrelated endogenous self pMHC-I complexes displayed on virus-infected cells. To elucidate the molecular recognition events on live CTL, we have utilized a self-assembled biosensor composed of semiconductor nanocrystals, quantum dots, carrying a controlled number of virus-derived (cognate) and other (noncognate) pMHC-I complexes and examined their recognition by antigen-specific T...
Expand abstract - Publisher copy:
- 10.1073/pnas.0607771103
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 103
- Issue:
- 45
- Pages:
- 16846-16851
- Publication date:
- 2006-11-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:3d7a78d9-5bcb-41aa-a435-f5bdd5de567a
- Source identifiers:
-
482604
- Local pid:
- pubs:482604
- Copyright date:
- 2006
Journal article
Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.
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