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Dihydrofolate-reductase mutations in Plasmodium knowlesi appear unrelated to selective drug pressure from putative human-to-human transmission in Sabah, Malaysia

Abstract:

Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. We sought evidence of drug selection pressure from the antimalarial sulfadoxine-pyrimethamine (SP) as a potential marker of H-H transmission.The P. knowlesi dihdyrofolate-reductase (pkdhfr) gene was sequenced from 449 P. knowlesi malaria cases from Sabah (Malaysian Borneo) and genotypes...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0149519

Authors


Barber, BE More by this author
Marfurt, J More by this author
William, T More by this author
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Funding agency for:
White, NJ
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
11
Issue:
3
Pages:
e0149519
Publication date:
2016
DOI:
EISSN:
1932-6203
URN:
uuid:3d7568a1-e190-4025-8797-882d8eafa71e
Source identifiers:
609081
Local pid:
pubs:609081
Language:
English

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