Journal article
Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.
- Abstract:
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BACKGROUND: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesis by the induction of VSG RNAi triggers an unusually precise precytokinesis cell-cycle arrest. METHODOLOGY/PRINCIPAL FINDINGS: Here, we characterise the cells arrested after the induction of VSG RNAi. We were able to rescue the VSG221 RNAi induc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 714.0KB)
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- Publisher copy:
- 10.1371/journal.pone.0007532
Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 4
- Issue:
- 10
- Article number:
- e7532
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:3d6e8e30-4634-455c-bb24-d24c89673e9a
- Local pid:
- pubs:9749
- Source identifiers:
-
9749
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Smith et al
- Copyright date:
- 2009
- Notes:
- Copyright 2009 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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